Recently, reports have shown that gastric cancer has high abundance in Iran and is at the second level in men, and fourth in total. This study aimed to determine the 5-year survival of gastric cancer patients and to investigate factors affecting the performance, based on TNM-7 staging system. In this study, we investigated 760 patients with gastric cancer since the beginning of 1993 to the end of 2006 in the Iran Cancer Institute who underwent surgery. Survival of these patients was determined after surgery, and the effects of demographic characteristics such as age (during operation), sex, and information on diseases such as cancer site, pathologic type, stage of disease progress (Stage), metastasis and sites of metastases were evaluated. The 5 -year survival probability of patients was 28 %, and median survival time was 25.69 months. Univariate tests showed that sex, cancer site, and pathologic type have no significant effects on patient’s survival. But the probability of 5-year survival significantly decreases with increasing age, and as it is expected, those with metastases were significantly less likely to have 5-year survival, and disease stage was significantly effective on patients’ life (P<0.001). Simultaneous evaluation of different variables’ effects on the probability of survival using the multiple Cox proportional hazards models showed that age and stage disease variables were effective on the survival of patients. The 5-year survival of patients with gastric cancer is low in Iran, although it is improved compared to the past. It seems that one of the main reasons for low survival rate of these patients is a late referral of patients for diagnosis and treatment. Most patients refer in the final stages of the disease, at this stage most patients are affected by lymph nodes metastases, liver and as the result, their treatment will be more difficult.

PURPOSE: To evaluate the influence of perinephric fat infiltration and tumor size on survival of patients with renal cell carcinoma (RCC). MATERIALS AND METHODS: We have retrospectively reviewed the records of 338 consecutive patients with pT1-3aN0M0 RCC، including 275 pT1-2 and 63 pT3a tumors، who underwent open partial or radical nephrectomy between 1995 and 2008. Univariate and multivariate analyses were performed in order to evaluate the prognostic factors. RESULTS: Median follow-up period was 36. 07 months. Receiver Operating Characteristic curve analysis determined the optimal tumor size cutoff value as 7 cm (Area Under the Curve: 0. 65 ± 0. 047; 95% Confidence Interval: 0. 558 to 0. 741). Perinephric fat invasion and Fuhrman grade were independent prognostic factors for disease-specific survival (DSS). In patients with tumor size >7 cm، perinephric fat invasion affected DSS significantly. Tumor size (according to the cutoff value of 7 cm) significantly affected DSS in patients with pT3a disease. According to the TNM 2002 staging system، perinephric fat invasion did not have any significant effect on DSS in patients with tumor size smaller than 4 cm، unlike tumor size of 4 to 7 cm and >7 cm. pT3a tumors larger than 7 cm demonstrated the worst prognosis compared to other groups. CONCLUSION: Perinephric fat invasion was demonstrated as a significant prognostic factor for RCC patients with tumor size >4 cm. Consequently، evaluation of pT3a patients should take tumor size into consideration for better prognostic analysis.

Background: This research aimed to investigate diagnostic value of preoperative chest computed tomography (CT) in the staging of clinical tumor-node-metastasis (TNM) in non-small cell lung cancer (NSCLC). Materials and Methods: Hundred and ninety eight patients with NSCLC accepted by the Affiliated Hospital of Shaoxing University (Shaoxing Municipal Hospital) from June 2021 to October 2022 were retrospectively selected as the study subjects. Preoperative multislice spiral computed tomography (MSCT) examination was performed, and the results of pathological examination were the gold standard to evaluate accuracy of CT diagnosis of TNM staging. Results: The staging accuracy of CT diagnosis was 86% for T1, 85.34% for T2, 76.92% for T3, and 66.7% for T4, with an overall accuracy of 83.83%. The Kappa value was 0.744. For nodal staging, the accuracy of CT diagnosis was 85.34% for stage N0, 67.86% for stage N1, and 72.22% for stage N2, yielding an overall accuracy of 79.29%. The Kappa value for nodal staging was 0.702. In terms of specific stages, the accuracy of CT diagnosis was 80.39% for stage IA, 81.40% for IB, 59.38% for IIA, 76.47% for IIB, and 73.21% for IIIA, with an overall accuracy of 75.25%. The Kappa value for these stages was 0.701. Conclusion: The clinical T stage, N stage, and TNM stage diagnosed by CT before surgery were consistent with the pathological T stage after surgery, especially in the early stage of LC.

This study was designed to investigate the value of red blood cell distribution width (RDW), prealbumin (PA), platelet to lymphocyte ratio (PLR), and carcinoembryonic antigen (CEA) in the diagnosis of colorectal cancer.  There was  500 colorectal cancer (CRC) patients, 250 polyps of colorectal patients, and 250 healthy volunteers performed to complete blood counts with automated differential counts. The differences in RDW, PA, PLR, and CEA among the three groups were statistically significant (P<0.05). RDW, PA, PLR, CEA, and RDW+PA+PLR+CEA all had a high accuracy rate for the diagnosis of colorectal cancer. RDW, PA, PLR, CEA, and RDW+PA+PLR+CEA were divided into high-expression groups and low-expression groups according to ROC cut-off values. Age was statistically different between the high and low groups in RDW, PA, and CEA. M staging was statistically different between high and low groups in CEA, and PLR. T staging was statistically different between high and low groups in PA, CEA, PLR, and RDW+PA+CEA+ PLR. N staging and blood vessel invasion were statistically different between the high and low groups in CEA. TNM staging was statistically different between high and low groups in PA, CEA, PLR, and RDW+PA+CEA+PLR. Perineural invasion was statistically different between the high and low groups in PA and CEA. The number of lymph node metastases was significantly and positively correlated with CEA. CEA and PLR were independent risk factors for the TNM staging. And they had good diagnostic efficacy for the TNM staging of colorectal cancer.

Background: This study detected osteopontin (OPN) and matrix metalloproteinase-7 (MMP-7) expressions to explore the roles of OPN and MMP-7 in the occurrence, progression, and prognosis of nonsmall cell lung cancer (NSCLC). Materials and Methods: A retrospective study was conducted on NSCLC tissues (n=152; case group) and adjacent nonneoplastic lung parenchyma (adjacent to tumor>5 cm; n=152; control group) collected from 152 NSCLC patients. The protein expressions of OPN and MMP-7 were detected by immunohistochemistry. OPN and MMP-7 messenger RNA (mRNA) expressions were detected by reverse transcription polymerase chain reaction (RT-PCR).Results: The protein and mRNA expressions of OPN and MMP-7 in NSCLC tissues were evidently higher than those in adjacent nonneoplastic lung parenchyma (all P<0.05). OPN protein and mRNA expression were associated with the degree of differentiation, tumor node metastasis (TNM) staging, and lymph node metastasis in NSCLC (all P<0.05). MMP-7 protein expression was associated with TNM staging and lymph node metastasis (both P<0.05) while MMP-7 mRNA expression was associated with the degree of differentiation, TNM staging, and lymph node metastasis (all P<0.05). A significantly positive relativity was revealed between OPN expression and MMP-7 expression (protein: r=0.789, P<0.001; mRNA: r=0.377, P<0.001). Lymph node metastasis, TNM staging, OPN, and MMP-7 protein expressions were independent risk factors for the prognosis of NSCLC (all P<0.05).Conclusion: High MMP-7 and OPN protein expressions are closely related to the occurrence, progression, and prognosis of NSCLC, and can be served as unfavorable prognostic factors for NSCLC.